MODOT is preparing to replace a part of I-55 and that passes over Highway 61/34 at Center Junction in Cape Girardeau.
The 50-year-old bridge is rough due to potholes and wear.
Construction is set to take place over the summers of 2019 and 2020.
Highway 61/34 will be changed to a diverging diamond interchange which allows drivers to switch sides at the intersection to allow easier turns.
The project is intended to let traffic move more smoothly through the area.